Gene expression in actinic keratoses: pharmacological modulation by imiquimod
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F04%3A00000964" target="_blank" >RIV/00216208:11120/04:00000964 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Gene expression in actinic keratoses: pharmacological modulation by imiquimod
Original language description
Background Actinic keratoses (AKs) are premalignant lesions that can progress into squamous cell carcinoma. Imiquimod, which belongs to the new class of immune-response modifiers, was recently shown to be effective in the treatment of AKs. The underlyingmechanisms are not fully understood. Objectives To study the expression of individual genes in uninvolved skin and AKs before therapy and to elucidate the way in which the expression of these genes is influenced by imiquimod therapy. Methods We treated13 patients with AK with imiquimod and compared gene expression before, during (five patients) and after (eight patients) therapy with that in uninvolved skin. We analysed genes coding for inflammatory cytokines or their receptors, adhesion molecules, anti-apoptotic proteins, p53 and toll-like receptors (TLRs) by reverse-transcriptase polymerase chain reaction. Results Comparing uninvolved skin and untreated AK, we found significant differences in the expression of interleukin (IL)-6, hu
Czech name
Genová exprese u aktinických keratóz: farmakologická modulace imiquimodem
Czech description
Aktinické keratózy jsou prekancerózy, které se mohou transformovat na spianliom. Imiquimod je určen k léčbě aktinických keratóz. Ve skupině 13 pacientů byla sledována genová exprese před, během a po terapii. Byly vyšetřovány geny, které kódují prozánětlivé cytokiny nebo jejich receptory, adhezivní molekuly, antiapoptotické proteiny, p53 a toll-like receptory s použitím RT-PCR. Bylo prokázáno, že lze najít specifické rozdíly v genové expresi mezi aktinickými keratózami a nepostiženou kůží
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FO - Dermatology and venereology
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2004
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
British Journal of Dermatology
ISSN
0007-0963
e-ISSN
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Volume of the periodical
151
Issue of the periodical within the volume
6
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
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UT code for WoS article
000225628700005
EID of the result in the Scopus database
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