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CCR1 blockade reduces interstitial inflammation and fibrosis in mice with glomerulosclerosis and nephrotic syndrome

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F04%3A00000975" target="_blank" >RIV/00216208:11120/04:00000975 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    CCR1 blockade reduces interstitial inflammation and fibrosis in mice with glomerulosclerosis and nephrotic syndrome

  • Original language description

    Background. CC chemokines mediate leukocyte infiltration into inflamed tissue. We have recently shown that blockade of the CC chemokine receptor CCR1 reduces interstitial inflammation and fibrosis in murine obstructive nephropathy. However, it is not known whether CCR 1 blockade is protective in progressive renal injury associated with severe proteinuria. We therefore studied the effect of the small-molecule CCR1 antagonist BX471 in a murine model of adriamycin-induced focal segmental glomerulosclerosis(FSGS) with nephrotic syndrome and progressive interstitial inflammation and fibrosis. Methods. Adriamycin nephropathy with persistent proteinuria was induced in male BALB/c mice by two intravenous injections of adriamycin (13 mg/kg) at day 0 and 14. BX471 treatment was started at day 14 when proteinuria and interstitial inflammation had developed. At 6 weeks, renal histology was studied by morphometry and immunohistochemistry. Results. At week 6, adriamycin-treated mice showed FSGS, as

  • Czech name

    Blokáda CCR1 snižuje zánětlivou infiltraci a fibrózu intersticia u myší s glomerulosklerózou a nefrotickým syndromem

  • Czech description

    Autoři zkoumali vliv blokátoru CCR1 chemokinového receptoru BX471 u myššího modelu adriamycinem indukované fokálně segmentální glomerulosklerózy, onemocnění charakterizovaného nefrotickým syndromem a progredující fibrózou intersticia ledviny. BX471 výrazně redukuje počet makrofágů a T lymfocytů v intersticiu adriamycinem poškozených ledvin. Počet intersticiálních fibroblastů a objem intersticia ledviny byly léčbou BX471 sníženy oproti neléčenému divokému kmeni, naopak na rozvoj glomerulosklerózy a proteinurie neměla léčba vliv. Blokáda CCR1 může být novou terapeutickou strategií u progresivních nefropatií, jako je FSGS.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FE - Other fields of internal medicine

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2004

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Kidney International

  • ISSN

    0085-2538

  • e-ISSN

  • Volume of the periodical

    66

  • Issue of the periodical within the volume

    6

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    15

  • Pages from-to

  • UT code for WoS article

    000225026200016

  • EID of the result in the Scopus database