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GABA(B) receptor agonist baclofen has non-specific antinociceptive effect in the model of peripheral neuropathy in the rat

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F04%3A00001110" target="_blank" >RIV/00216208:11120/04:00001110 - isvavai.cz</a>

  • Alternative codes found

    RIV/68407700:21460/04:12141321

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    GABA(B) receptor agonist baclofen has non-specific antinociceptive effect in the model of peripheral neuropathy in the rat

  • Original language description

    Specific GABAB receptor agonist baclofen is used in clinical practice for the treatment of spasticity but it also exerts an analgesic effect. In this work we describe this effect, which was attenuated in the model of chronic neuropathic pain, probably due to the degeneration of GABA interneurons after chronic constriction injury.

  • Czech name

    Agonista GABA(B) receptoru baklofen má u modelu periferní neuropatie nespecifický antinocicepční účinek

  • Czech description

    Specifický agonista GABA(B) receptoru baklofen se vklinické praxi používá při léčbě spasticity, ale má také analgetický efekt. Práce se zabývá analgetickým účinkem baklofenu u modelu chronické neuropatické bolesti. Tento efekt je zde oslaben, pravděpodobně kvůli degeneraci GABA interneuronů vmíše.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    ED - Physiology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2004

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Physiological Research

  • ISSN

    0862-8408

  • e-ISSN

  • Volume of the periodical

    53

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    5

  • Pages from-to

    351-355

  • UT code for WoS article

  • EID of the result in the Scopus database