The phenotypes of bipolar disorder: relevance for genetic investigations

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F05%3A00001150" target="_blank" >RIV/00216208:11120/05:00001150 - isvavai.cz</a>
Alternative codes found
RIV/00023752:_____/05:00000880
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
The phenotypes of bipolar disorder: relevance for genetic investigations
Original language description
The search for susceptibility genes for bipolar disorder ( BD) depends on appropriate definitions of the phenotype. In this paper, we review data on diagnosis and clinical features of BD that could be used in genetic studies to better characterize patients or to define homogeneous subgroups. Clinical symptoms, long-term course, comorbid conditions, and response to prophylactic treatment may define groups associated with more or less specific loci. One such group is characterized by symptoms of psychosisand linkage to 13q and 22q. A second group includes mainly bipolar II patients with comorbid panic disorder, rapid mood switching, and evidence of chromosome 18 linkage. A third group comprises typical BD with an episodic course and favourable responseto lithium prophylaxis. Reproducibility of cognitive deficits across studies raises the possibility of using cognitive profiles as endophenotypes of BD, with deficits in verbal explicit memory and executive function commonly reported. Bra
Czech name
Fenotypy bipolárního onemocnení: relevance pro genetické výzkumy
Czech description
Autoři popisují fenotypy bipolárního onemocnení a jejich relevanci pro genetické výzkumy

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FL - Psychiatry, sexology
OECD FORD branch
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Publication year
2005
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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