Different Environmental Influences on Aetiology of Atopic Diseases in European Populations as a Basis for Study of Gene-Environment Interactions
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F08%3A00000994" target="_blank" >RIV/00216208:11120/08:00000994 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
Different Environmental Influences on Aetiology of Atopic Diseases in European Populations as a Basis for Study of Gene-Environment Interactions
Original language description
Atopy is a predisposition to hyperproduction of immunoglobulin E (IgE) against common environmental allergens.. The development of these diseases is influenced by both genetic and environmental factors. As the first step in study of such gene-environmentinteractions we analyzed the specificity and intensity of sensitization to 40 different allergens in atopic patients from the Czech Republic and Ukradne. We found highly significant differences in sensitization to airborne allergens between patients from the two countries. The most pronounced allergens from Ukradne were dust mites allergens and cat. In the atopic patients from the Czech Republic the level of sensitization to these allergens was similar, but the level of sensitization to outdoor allergens, grasses and trees was dramatically higher. The higher sensitization levels to outdoor allergens in the Czech Republic suggest an influence of westernization on development of allergic reactivity.
Czech name
Odlišné vlivy prostředí na etiologii atopických chorob v evropských populacích jako základ studia interakce genů a okolního prostředí
Czech description
Atopie je predispozice k hyperprodukci IgE proti okolním alergenům. Vývoj nemoci je ovlivněn vlivy genetickými a prostředím. Analyzovali jsme specifitu a intenzitu senzibilizace proti alergenům u atopických pacientů v České republice a na Ukrajině. Bylynalezeny významné rozdíly, nejvýznamnější alergeny na Ukrajině byly z roztočů a z koček, v ČR byla vyšší senzibilizace proti pylovým alergenům. Tento nález může odrážet vliv západního životního stylu na populaci.
Classification
Type
C - Chapter in a specialist book
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
—
Result continuities
Project
—
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2008
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Genetic Predisposition to Disease
ISBN
978-1-60456-835-6
Number of pages of the result
14
Pages from-to
—
Number of pages of the book
278
Publisher name
Nova Science Publishers
Place of publication
New York
UT code for WoS chapter
—