The influence of polymorphism for gene RGS4 (Regulator of G-protein Signaling 4) on regional brain metabolism (18FDG PET) and phenotypic variables in schizophrenia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F09%3A00002092" target="_blank" >RIV/00216208:11120/09:00002092 - isvavai.cz</a>

Alternative codes found

RIV/00023752:_____/09:00000960

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The influence of polymorphism for gene RGS4 (Regulator of G-protein Signaling 4) on regional brain metabolism (18FDG PET) and phenotypic variables in schizophrenia

Original language description

RGS4 represents a positional and functional candidate gene for schizophrenia confirmed by several studies in independent samples. In a group of 63 patients with schizophrenia, we have genotyped four SNPs (1,4,7,18) which have previously been associated with schizophrenia, individually or as part of haplotype. We evaluated the influence of candidate SNPs on phenotypic characteristics and regional brain metabolism measured by 18FDG PET. Neuroimaging data were treated by SPM99. We found lower metabolism bilaterally in basal ganglia (p<=0.05, corrected) in the risky G-allele carriers in SNP 7. In SNP 1, the trend for lower metabolism associated with the G-allele in the right prefrontal cortex was detected (p<=0.001). The risky G-allele was connected with lower expression of negative symptoms (SNP7) and later onset of schizophrenia (SNP 7,18).Our results support the role of basal ganglia and the prefrontal cortex in the mechanism of how the RGS4 polymorphism influrences schizophrenia. We fo

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/NR9324" target="_blank" >NR9324: The candidate genes for schizophrenia: the influence on phenotypic variability in patients and in vitro manipulation of gene expression by the use of siRNA.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Psychiatrie

ISSN

1211-7579

e-ISSN

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Volume of the periodical

13

Issue of the periodical within the volume

Suppl. 3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

4

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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