The role of prolactin in immune response to bacterial infection
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F09%3A00002109" target="_blank" >RIV/00216208:11120/09:00002109 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
The role of prolactin in immune response to bacterial infection
Original language description
Interactions between the neuroendocrine and immune system play an important role in maintaining and restoring homeostasis. Any dysfunction may result in susceptible individuals in septicemia and bacterial infection. We studied toll-like receptors (TLR) and prolactin (PRL) role in defensive reaction of immune system to bacterial infection and hypothesized that PRL takes part in this defensive reaction and has contraregulative role against activation of adrenocortical system. Measuring the expression of PRL, TLR 2 and 4 mRNA levels in CD14+ cells derived from peripheral blood of 20 septic patients at the time of admission (sample A) and then at the moment when symptoms of sepsis disappeared (sample B) revealed no change between the two samples. Similarly, we were not able to detect any statistically significant difference in PRL, TLR2 and 4 protein levels measured by FCM. Preliminary results do not confirm that septic statuses change peripheral PRL, TLR2 and TLR4 expression in CD14+ cell
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
EC - Immunology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NS9970" target="_blank" >NS9970: The role of prolactin in immune response to bacterial infection</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Proceeding of the 2nd European Congress of Immunology
ISBN
978-88-7587-523-7
ISSN
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e-ISSN
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Number of pages
4
Pages from-to
27-30
Publisher name
Medimond
Place of publication
Bologna
Event location
Berlin
Event date
Sep 13, 2009
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
000292190700006