White Matter Changes in Normal Pressure Hydrocephalus, a Possible Marker for the White Matter Damage

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F10%3A00002950" target="_blank" >RIV/00216208:11120/10:00002950 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
White Matter Changes in Normal Pressure Hydrocephalus, a Possible Marker for the White Matter Damage
Original language description
Objective: The etiology of normal pressure hydrocephalus (NPH) remains enigmatic. The search for reliable markers of the disease for non invasive diagnostics and for the etiology of the disease is constantly needed. One of the hypotheses for gait impairment in NPH is the affection of periventricular white matter. Methods: In this study 18 patients were investigated for possible NPH. All patients underwent diagnostic testing including the lumbar infusion test and 5 days of external lumbar drainage for diagnosis of normal pressure hydrocephalus. Eleven healthy individuals were examined with the same technique. Following parameters were then manually measured: fractional anisotropy (FA) and apparent diffusion coefficient (ADC) in fornix, genu of the internal capsule, and optic radiation. The ROI was placed two slices above the slice where anterior comissure could be detected. A Mann Whitney U test was used for the analysis of the results. Conclusion: The DTI measurements may reveal the wh
Czech name
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Czech description
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Project
<a href="/en/project/GPP304%2F10%2FP464" target="_blank" >GPP304/10/P464: Diffusion tensor imaging of pyramidal tract as predictor of normal pressure hydrocephalus treatment outcome</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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