Perinatal effect of methamphetamine on nociception in adult Wistar rats

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F11%3A00002415" target="_blank" >RIV/00216208:11120/11:00002415 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.ijdevneu.2010.08.004" target="_blank" >http://dx.doi.org/10.1016/j.ijdevneu.2010.08.004</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ijdevneu.2010.08.004" target="_blank" >10.1016/j.ijdevneu.2010.08.004</a>

Result language
angličtina
Original language name
Perinatal effect of methamphetamine on nociception in adult Wistar rats
Original language description
Methamphetamine is a psychostimulant drug which causes the release of monoamine neurotransmitters. Although drugs of abuse are known to have analgesic effects, there is a lack of evidence regarding the effect of prenatal exposure to methamphetamine on nociception in adulthood. Adult Wistar rats whose mothers had received daily exposure to methamphetamine (5 mg/kg; s.c.) or saline, during gestation or gestation and lactation periods, were examined for: (1) gender differences in nociception; (2) an association between nociception and gross-motor behavior in the plantar test; (3) effects of cross-fostering on nociception; and (4) analgesic effects of an acute injection of methamphetamine (1 mg/kg s.c.). Nociception was tested using the plantar test on postnatal days 85-90. Prenatal methamphetamine increased sensitivity to pain on forelimbs (p < 0.0001) and hind limbs (p < 0.05) in females only. Prenatal methamphetamine treated male rats fostered by adoptive injection stressed mothers had
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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