White matter hyperintensities in affected and unaffected late teenage and early adulthood offspring of bipolar parents: A two-center high-risk study

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F11%3A00002886" target="_blank" >RIV/00216208:11120/11:00002886 - isvavai.cz</a>
Alternative codes found
RIV/00023752:_____/11:00001135
Result on the web
<a href="http://dx.doi.org/10.1016/j.jpsychires.2010.04.019" target="_blank" >http://dx.doi.org/10.1016/j.jpsychires.2010.04.019</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jpsychires.2010.04.019" target="_blank" >10.1016/j.jpsychires.2010.04.019</a>

Result language
angličtina
Original language name
White matter hyperintensities in affected and unaffected late teenage and early adulthood offspring of bipolar parents: A two-center high-risk study
Original language description
White matter hyperintensities (WMHs) are among the most replicated neuroimaging findings in bipolar disorder (BD). It is not clear whether these lesions are an artifact of comorbid conditions, or whether they are directly associated with the disorder, oreven represent biological risk factor for BD. To test whether WMHs meet criteria for an endophenotype of BD, we conducted a high-risk design study and recruited 35 affected, 44 unaffected relatives of bipolar probands (age range 15e30 years), matched byage and sex with 49 healthy controls without any personal or family history of psychiatric disorders. The presence of WMHs was determined from Fluid Attenuated Inversion Recovery (FLAIR) scans acquired on a 1.5 Tesla scanner using a validated emi-quantitative scale. We found mostly low grade WMHs in all groups. The proportion of WMH-positive subjects was comparable between the unaffected high-risk, affected familial and control groups. White matter hyperintensities did not meet criteria
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
<a href="/en/project/NR8786" target="_blank" >NR8786: Detection of neuroanatomical risk factors for bipolar disorder</a><br>
Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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