Variation in the Vitamin D Receptor Gene is not Associated with Risk of Colorectal Cancer in the Czech Republic

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F11%3A00003210" target="_blank" >RIV/00216208:11120/11:00003210 - isvavai.cz</a>

Alternative codes found

RIV/68378041:_____/11:00347501

Result on the web

<a href="http://dx.doi.org/10.1007/s12029-010-9168-6" target="_blank" >http://dx.doi.org/10.1007/s12029-010-9168-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12029-010-9168-6" target="_blank" >10.1007/s12029-010-9168-6</a>

Result language

angličtina

Original language name

Variation in the Vitamin D Receptor Gene is not Associated with Risk of Colorectal Cancer in the Czech Republic

Original language description

Increased levels of vitamin D may protect against colorectal cancer (CRC) development and recurrence. Accumulating epidemiologic evidence suggests these effects may be partly mediated by genetic variants of the vitamin D receptor (VDR) proposed to be associated with altered risk of CRC. We wished to determine if common VDR polymorphisms affected CRC risk in the Czech Republic, a homogenous European population with a high CRC incidence rate. Frequencies of the common VDR gene polymorphisms rs2238136, rs1544410 (BsmI), rs7975232 (ApaI), and rs731236 (TaqI) were determined using allele-specific PCR in a case control analysis of a series of 754 CRC patients and 627 patients without malignant disease recruited from centers throughout the Czech Republic. Unconditional logistic regression was used to calculate odds ratios and 95% confidence intervals for the association between these variants and risk of CRC. None of the four polymorphisms tested had any significant effect on CRC risk. No significant differences were observed in susceptibility when the population was stratified by anatomical sub-site, sex, BMI, smoking, alcohol, or presence of polyps. We conclude that common variation in the VDR gene had little effect on its own on predisposition to sporadic CRC in the Czech population.

Czech name

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Czech description

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Type

J_SC - Article in a specialist periodical, which is included in the SCOPUS database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Gastrointestinal Cancer

ISSN

1941-6628

e-ISSN

1941-6636

Volume of the periodical

42

Issue of the periodical within the volume

3

Country of publishing house

US - UNITED STATES

Number of pages

6

Pages from-to

149-154

UT code for WoS article

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EID of the result in the Scopus database

2-s2.0-80054979850