Comparison of cinnarizine/dimenhydrinate fixed combination with the respective monotherapies for vertigo of various origins: a randomized, double-blind, active-controlled, multicentre study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F11%3A00003315" target="_blank" >RIV/00216208:11120/11:00003315 - isvavai.cz</a>

Alternative codes found

RIV/00064173:_____/11:#0000269

Result on the web

<a href="http://dx.doi.org/10.2165/11588920-000000000-00000" target="_blank" >http://dx.doi.org/10.2165/11588920-000000000-00000</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2165/11588920-000000000-00000" target="_blank" >10.2165/11588920-000000000-00000</a>

Result language

angličtina

Original language name

Comparison of cinnarizine/dimenhydrinate fixed combination with the respective monotherapies for vertigo of various origins: a randomized, double-blind, active-controlled, multicentre study

Original language description

Vertigo may arise from dysfunction in the peripheral and/or the central vestibular system. Simultaneous activity of a medication at both sites will serve to improve the efficacy of antivertigo treatment. The aim of this study was to compare the efficacyand tolerability of a fixed combination of the peripherally acting cinnarizine (20 mg) plus the centrally acting dimenhydrinate (40 mg) with those of equally dosed monotherapies in the treatment of vertigo of various origins. This prospective, randomized, double-blind, active-controlled, multicentre study included patients who assessed at least one vertigo symptom as being of at least medium intensity (>= 2) on a 5-point visual analogue scale (VAS; ranging from 0 = not present to 4 = very strong) and who had pathological vestibulospinal movement patterns and/or nystagmus reactions. The fixed combination of cinnarizine 20 mg/dimenhydrinate 40 mg was an effective and well tolerated treatment for patients with vestibular vertigo of central

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FF - ENT (ie. ear, nose, throat), ophthalmology, dentistry

OECD FORD branch

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Project

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Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical Drug Investigation

ISSN

1173-2563

e-ISSN

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Volume of the periodical

31

Issue of the periodical within the volume

6

Country of publishing house

NZ - NEW ZEALAND

Number of pages

13

Pages from-to

371-383

UT code for WoS article

000291175100002

EID of the result in the Scopus database

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