Epigenetic regulation of transcription and splicing of syncytins, fusogenic glycoproteins of retroviral origin

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F11%3A00003345" target="_blank" >RIV/00216208:11120/11:00003345 - isvavai.cz</a>

Alternative codes found

RIV/68378050:_____/11:00370438 RIV/00064173:_____/11:#0000182

Result on the web

<a href="http://dx.doi.org/10.1093/nar/gkr562" target="_blank" >http://dx.doi.org/10.1093/nar/gkr562</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/nar/gkr562" target="_blank" >10.1093/nar/gkr562</a>

Result language

angličtina

Original language name

Epigenetic regulation of transcription and splicing of syncytins, fusogenic glycoproteins of retroviral origin

Original language description

Syncytin-1 and -2, human fusogenic glycoproteins encoded by the env genes of the endogenous retroviral loci ERVWE1 and ERVFRDE1, respectively, contribute to the differentiation of multinucleated syncytiotrophoblast in chorionic villi. In non-trophoblastic cells, however, the expression of syncytins has to be suppressed to avoid potential pathogenic effects. We studied the epigenetic suppression of ERVWE1 and ERVFRDE1 5'-long terminal repeats by DNA methylation and chromatin modifications. Immunoprecipitation of the provirus-associated chromatin revealed the H3K9 trimethylation at transcriptionally inactivated syncytins in HeLa cells. qRT-PCR analysis of non-spliced ERVWE1 and ERVFRDE1 mRNAs and respective env mRNAs detected efficient splicing of endogenously expressed RNAs in trophoblastic but not in non-placental cells. Pointing to the pathogenic potential of aberrantly expressed syncytin-1, we have found deregulation of transcription and splicing of the ERVWE1 in biopsies of testicul

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nucleic Acids Research

ISSN

0305-1048

e-ISSN

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Volume of the periodical

39

Issue of the periodical within the volume

20

Country of publishing house

GB - UNITED KINGDOM

Number of pages

12

Pages from-to

8728-8739

UT code for WoS article

000296343400015

EID of the result in the Scopus database

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