Lipolytic effects of B-type natriuretic peptide (1-32) in adipose tissue of heart failure patients compared with healthy controls

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F11%3A00003376" target="_blank" >RIV/00216208:11120/11:00003376 - isvavai.cz</a>
Alternative codes found
RIV/00023001:_____/11:00002471
Result on the web
<a href="http://dx.doi.org/10.1016/j.jacc.2011.05.042" target="_blank" >http://dx.doi.org/10.1016/j.jacc.2011.05.042</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jacc.2011.05.042" target="_blank" >10.1016/j.jacc.2011.05.042</a>

Result language
angličtina
Original language name
Lipolytic effects of B-type natriuretic peptide (1-32) in adipose tissue of heart failure patients compared with healthy controls
Original language description
Our goal was to examine the role of B-type natriuretic peptide (BNP) in lipolysis regulation in heart failure (HF) patients. Enhanced adipose tissue lipolysis can contribute to myocardial lipid overload, insulin resistance, and cachexia in advanced HF. Natriuretic peptides were recently recognized to stimulate lipolysis in healthy subjects. 10 nondiabetic HF patients (New York Heart Association functional class III, 50% nonischemic etiology) and 13 healthy subjects (control subjects) of similar age, sex, and body composition underwent a microdialysis study of subcutaneous abdominal adipose tissue. Four microdialysis probes were simultaneously perfused with 0.1 mu M BNP(1-32), 10 mu M BNP(1-32), 10 mu M norepinephrine (NE) or Ringer's solution. Outgoingdialysate glycerol concentration (DGC) was measured as an index of lipolysis. BNP(1-32) exerts strong lipolytic effects in humans. Despite marked elevation of plasma immunoreactive BNP, the responsiveness of adipose tissue to BNP(1-32) i
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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