The Application of Vagus Nerve Stimulation and Deep Brain Stimulation in Depression

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F11%3A00003377" target="_blank" >RIV/00216208:11120/11:00003377 - isvavai.cz</a>

Alternative codes found

RIV/00023752:_____/11:00001130

Result on the web

<a href="http://dx.doi.org/10.1159/000325225" target="_blank" >http://dx.doi.org/10.1159/000325225</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000325225" target="_blank" >10.1159/000325225</a>

Result language

angličtina

Original language name

The Application of Vagus Nerve Stimulation and Deep Brain Stimulation in Depression

Original language description

Despite the progress in the pharmacotherapy of depression, there is a substantial proportion of treatment-resistant patients. Recently, reversible invasive stimulation methods, i.e. vagus nerve stimulation (VNS) and deep brain stimulation (DBS), have been introduced into the management of treatment-resistant depression (TRD). VNS has already received regulatory approval for TRD. This paper reviews the available clinical evidence and neurobiology of VNS and DBS in TRD. The principle of VNS is a stimulation of the left cervical vagus nerve with a programmable neurostimulator. VNS was examined in 4 clinical trials with 355 patients. VNS demonstrated steadily increasing improvement with full benefit after 6-12 months, sustained up to 2 years. Patients whoresponded best had a low-to-moderate antidepressant resistance. However, the primary results of the only controlled trial were negative. DBS involves stereotactical implantation of electrodes powered by a pulse generator into the specific

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuropsychobiology

ISSN

0302-282X

e-ISSN

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Volume of the periodical

64

Issue of the periodical within the volume

3

Country of publishing house

CH - SWITZERLAND

Number of pages

11

Pages from-to

170-181

UT code for WoS article

000294555300006

EID of the result in the Scopus database

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