Hypogonadotropic hypogonadism in a homozygous MC4R mutation carrier and the effect of sibutramine treatment on body weight and obesity-related health risks

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F11%3A00003396" target="_blank" >RIV/00216208:11120/11:00003396 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1159/000330763" target="_blank" >http://dx.doi.org/10.1159/000330763</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000330763" target="_blank" >10.1159/000330763</a>

Result language

angličtina

Original language name

Hypogonadotropic hypogonadism in a homozygous MC4R mutation carrier and the effect of sibutramine treatment on body weight and obesity-related health risks

Original language description

The first aim of our study was to define the hypogonadism manifested by low testosterone levels and incomplete male secondary sex characteristics in a 20-year-old male homozygous MC4R mutation carrier (G181D). The second aim of our study was to evaluatethe effect of the anti-obesity drug sibutramine in this patient who failed to respond to an intensive lifestyle intervention and exhibited continuous weight gain. Anthropometric, biochemical, hormonal and psychobehavioural parameters were investigated both at baseline and after a 1-year sibutramine treatment. To characterise the hypogonadism, sex steroid profile, concentrations of luteinizing hormone and follicle-stimulating hormone were determined. Standard tests with gonadotropin-releasing hormone, thyrotropin-releasing hormone and human chorionic gonadotropin were conducted. Brain magnetic resonance imaging was performed to exclude organic hypothalamic-pituitary lesions. Clinical examination and endocrine investigations revealed hypo

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Obesity Facts

ISSN

1662-4025

e-ISSN

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Volume of the periodical

4

Issue of the periodical within the volume

4

Country of publishing house

CH - SWITZERLAND

Number of pages

5

Pages from-to

324-328

UT code for WoS article

000294763300011

EID of the result in the Scopus database

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