The effects of beta-glucan isolated from Pleurotus ostreatus on methotrexate treatment in rats with adjuvant arthritis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F11%3A00003404" target="_blank" >RIV/00216208:11120/11:00003404 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s00296-009-1258-z" target="_blank" >http://dx.doi.org/10.1007/s00296-009-1258-z</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00296-009-1258-z" target="_blank" >10.1007/s00296-009-1258-z</a>
Alternative languages
Result language
angličtina
Original language name
The effects of beta-glucan isolated from Pleurotus ostreatus on methotrexate treatment in rats with adjuvant arthritis
Original language description
The purpose of this study was to evaluate the effect of beta-(1,3/1,6)-d-glucan isolated from Pleurotus ostreatus (beta-glucan-PO) on prophylactic treatment of adjuvant arthritis (AA) with methotrexate (MTX) in rats. Groups of rats with AA were treated with methotrexate (1 mg/kg/week), beta-glucan-PO (1 mg/kg every second day) or their combination for the period of 28 days from adjuvant application. Body mass, hind paw swelling, arthrogram scores and a level of serum albumin were measured as markers ofinflammation and arthritis. Treatment with low dose of MTX significantly inhibited the markers of both inflammation and arthritis. MTX and its combination with beta-glucan-PO significantly increased body mass of arthritic rats. beta-glucan-PO administered alone significantly decreased both the hind paw swelling and arthritic score. In combination with MTX, beta-glucan-PO markedly potentiated the beneficial effects of MTX, which resulted in a more significant reduction of hind paw swellin
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Rheumatology International
ISSN
0172-8172
e-ISSN
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Volume of the periodical
31
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
507-511
UT code for WoS article
000288508500011
EID of the result in the Scopus database
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