Classification and discrimination of pediatric patients undergoing open heart surgery with and without methylprednisolone treatment by cytomics
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F11%3A43905933" target="_blank" >RIV/00216208:11120/11:43905933 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1117/12.876487" target="_blank" >http://dx.doi.org/10.1117/12.876487</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1117/12.876487" target="_blank" >10.1117/12.876487</a>
Alternative languages
Result language
angličtina
Original language name
Classification and discrimination of pediatric patients undergoing open heart surgery with and without methylprednisolone treatment by cytomics
Original language description
Methylprednisolone (MP) is frequently preoperatively administered in children undergoing open heart surgery. The aim of this medication is to inhibit overshooting immune responses. Earlier studies demonstrated cellular and humoral immunological changes in pediatric patients undergoing heart surgeries with and without MP administration. Here in a retrospective study we investigated the modulation of the cellular immune response by MP. The aim was to identify suitable parameters characterizing MP effectsby cluster analysis. Blood samples were analysed from two aged matched groups with surgical correction of septum defects. Group without MP treatment consisted of 10 patients; MP was administered on 21 patients (median dose: 11mg/kg) before cardiopulmonary bypass (CPB). EDTA anticoagulated blood was obtained 24 h preoperatively, after anesthesia, at CPB begin and end (CPB2), 4h, 24h, 48h after surgery, at discharge and at out-patient follow-up (8.2; 3.3-12.2 month after surgery; median an
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Result continuities
Project
—
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
Imaging, Manipulation, and Analysis of Biomolecules, Cell and Tissue IX
ISBN
978-0-81948-439-0
ISSN
0277-786X
e-ISSN
—
Number of pages
11
Pages from-to
"Art. Nr. 79021O"
Publisher name
International Society for Optical Engineering
Place of publication
Bellingham
Event location
San Francisco, CA
Event date
Jan 22, 2011
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000297677500039