Evaluation of lipofuscin-like pigments as an index of lead-induced oxidative damage in the brain
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F12%3A00003244" target="_blank" >RIV/00216208:11120/12:00003244 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/12:8014 RIV/00216208:11140/12:10118746 RIV/75010330:_____/12:00009895
Result on the web
<a href="http://dx.doi.org/10.1016/j.etp.2010.06.005" target="_blank" >http://dx.doi.org/10.1016/j.etp.2010.06.005</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.etp.2010.06.005" target="_blank" >10.1016/j.etp.2010.06.005</a>
Alternative languages
Result language
angličtina
Original language name
Evaluation of lipofuscin-like pigments as an index of lead-induced oxidative damage in the brain
Original language description
This study was carried out to investigate the role of lead in the development of oxidative stress in the brain. We examined the rate of lipid peroxidation and we determined lipid fluorescence products (lipofuscin-like pigments - LFP) as a marker of lipidperoxidation after short in vitro incubation of rat brain homogenates with lead acetate (10-2, 10-4, 10-6 M lead acetate, 2 h). Simultaneously we examined by the same method in vivo indices of oxidative stress in brains of mice exposed for 12 weeks to 0.2% lead acetate in drinking water. The results show that the concentration of LFP in rat brain homogenates increased significantly after 2 h incubation with 10-2 M lead acetate as compared to controls (P < 0.0001). This effect was not observed in lowerdoses of lead acetate (10-4 and 10-6 M). After the long-term exposure of mice to 0.2% lead acetate, pronounced accumulation of lead and significantly increased concentration of LFP (P < 0.004) in the brains of exposed animals as compared
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
<a href="/en/project/OC%20152" target="_blank" >OC 152: Functional and morphological study of brain plasticity in healthy and neurodefective mice under various condition</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Experimental and Toxicologic Pathology
ISSN
0940-2993
e-ISSN
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Volume of the periodical
64
Issue of the periodical within the volume
1-2
Country of publishing house
DE - GERMANY
Number of pages
6
Pages from-to
51-56
UT code for WoS article
000299030400008
EID of the result in the Scopus database
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