Aminopyridine Treatment in a Patient With Bilateral Vestibular Failure and Cryptogenic Downbeat Nystagmus

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F12%3A43896082" target="_blank" >RIV/00216208:11120/12:43896082 - isvavai.cz</a>

Alternative codes found

RIV/00064173:_____/12:43896082

Result on the web

<a href="http://dx.doi.org/10.1097/WNO.0b013e31824f397f" target="_blank" >http://dx.doi.org/10.1097/WNO.0b013e31824f397f</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/WNO.0b013e31824f397f" target="_blank" >10.1097/WNO.0b013e31824f397f</a>

Result language

angličtina

Original language name

Aminopyridine Treatment in a Patient With Bilateral Vestibular Failure and Cryptogenic Downbeat Nystagmus

Original language description

In a recent issue of this journal, Kalla et al (1) reported that 4-aminopyridine (4-AP) alleviates the symptoms of downbeat nystagmus (DBN) significantly more than 3,4-diaminopyridine (3,4-DAP). Both drugs are potassium-channel blockers, but 4-aminopyridine is lipid-soluble and more easily crosses the blood-brain-barrier. 3,4-diaminopyridine is not lipid soluble, with direct effects in the peripheral nervous system and indirect effects in the central nervous system via its metabolites (1,2). In the report by Kalla et al (1), 1 male patient suffered from bilateral vestibular failure (disorder of the peripheral nervous system) as well as DBN (disorder of the central nervous system). We now document this case in detail. At the time of the study, the patient was 58 years old. Ten years earlier, he had traveled to Indonesia, where he suffered from extreme diarrhea with severe weight loss, followed by the development of tinnitus, oscillopsia, postural instability, and bilateral vestibular fa

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FF - ENT (ie. ear, nose, throat), ophthalmology, dentistry

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Neuro-Ophthalmology

ISSN

1070-8022

e-ISSN

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Volume of the periodical

32

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

1

Pages from-to

190

UT code for WoS article

000304790500019

EID of the result in the Scopus database

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