Gender differences in behavioral changes elicited by prenatal methamphetamine exposure and application of the same drug in adulthood

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F13%3A43896925" target="_blank" >RIV/00216208:11120/13:43896925 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1002/dev.21016" target="_blank" >http://dx.doi.org/10.1002/dev.21016</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/dev.21016" target="_blank" >10.1002/dev.21016</a>

Result language

angličtina

Original language name

Gender differences in behavioral changes elicited by prenatal methamphetamine exposure and application of the same drug in adulthood

Original language description

The aim of the present study was to compare the response to sub-chronic application of methamphetamine (MA) in adulthood in male and female rats prenatally exposed to the same drug. The spontaneous locomotor activity and exploratory behavior of adult male and female rats prenatally exposed to 5 mg/kg MA or saline (SAL) were tested in a Laboras apparatus (Metris B.V., Netherlands) for five consecutive days, 1 hr daily. MA 1 mg/kg or SAL were used as a challenge prior to testing. Our results showed that rats prenatally exposed to MA were more sensitive to sub-chronic administration of MA in adulthood than prenatally SAL-exposed rats. However, this sensitizing effect of prenatal MA exposure was manifested differently in males and females. In contrast, prenatal MA exposure decreased baseline locomotion in females. This study indicates that gender plays an important role in the sensitivity to MA during prenatal development and in adulthood

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Developmental Psychobiology

ISSN

0012-1630

e-ISSN

—

Volume of the periodical

55

Issue of the periodical within the volume

3

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

232-242

UT code for WoS article

000316464400003

EID of the result in the Scopus database

—