Differential effect of baclofen on cortical and spinal inhibitory circuits

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F13%3A43906099" target="_blank" >RIV/00216208:11120/13:43906099 - isvavai.cz</a>

Alternative codes found

RIV/00023884:_____/12:00007614

Result on the web

<a href="http://dx.doi.org/10.1016/j.clinph.2012.07.005" target="_blank" >http://dx.doi.org/10.1016/j.clinph.2012.07.005</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.clinph.2012.07.005" target="_blank" >10.1016/j.clinph.2012.07.005</a>

Result language

angličtina

Original language name

Differential effect of baclofen on cortical and spinal inhibitory circuits

Original language description

The cutaneous silent period (SP) is a spinal inhibitory reflex, which suppresses activity in spinal motor nuclei. Transcranial magnetic stimulation (TMS) elicits a cortical SP, which represents GABA(B) receptor-mediated inhibition of cortical excitability. Baclofen as a strong GABA(B) agonist effectively reduces muscle hypertonia, however, it is not known whether intrathecal baclofen (ITB) may modulate spinal inhibitory circuits. We evaluated clinical and neurophysiological effects of ITB in ten patients with severe spasticity due to spinal cord injury (n=9) and chronic progressive multiple sclerosis (n=1). Neurophysiological assessment included H reflex and cutaneous and cortical SPs, before and 15, 30, 60, 90, 120, and 180min after ITB bolus administration. RESULTS: ITB suppressed soleus H reflex as early as 15min after lumbar bolus injection; MAS scores declined after 1h. Cortical SP end latency and duration increased progressively with a significant maximum 3h following ITB bolus,

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

<a href="/en/project/NT12282" target="_blank" >NT12282: Pathophysiological mechanisms of neuromodulation therapy in dystonia</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical Neurophysiology

ISSN

1388-2457

e-ISSN

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Volume of the periodical

124

Issue of the periodical within the volume

2

Country of publishing house

IE - IRELAND

Number of pages

7

Pages from-to

339-345

UT code for WoS article

000313592400015

EID of the result in the Scopus database

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