Weight Loss Improves the Adipogenic Capacity of Human Preadipocytes and Modulates their Secretory Profile
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F13%3A43907081" target="_blank" >RIV/00216208:11120/13:43907081 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.2337/db12-0986" target="_blank" >http://dx.doi.org/10.2337/db12-0986</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2337/db12-0986" target="_blank" >10.2337/db12-0986</a>
Alternative languages
Result language
angličtina
Original language name
Weight Loss Improves the Adipogenic Capacity of Human Preadipocytes and Modulates their Secretory Profile
Original language description
Calorie restriction-induced weight loss is accompanied by profound changes in adipose tissue characteristics. To determine the effect of weight loss on differentiation of preadipocytes and secretory capacity of in vitro differentiated adipocytes, we established cultures of these cells from paired subcutaneous adipose tissue biopsies obtained before and at the end of weight-reducing dietary intervention in 23 obese women. Based on lipid accumulation and the expression of differentiation markers, in vitroadipogenesis increased following weight loss and it was accompanied by enhanced expression of genes involved in de novo lipogenesis. This effect of weight loss was not driven by changes of PPAR sensitivity to rosiglitazone. Weight loss also enhanced theexpression of adiponectin and leptin while reducing that of MCP1 and IL8 by cultured adipocytes.Thus, the weight-reducing dietary intervention increased adipogenic capacity of preadipocytes and shifted their secretion towards lower infla
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GAP301%2F11%2F0748" target="_blank" >GAP301/11/0748: The role of endoplasmic reticulum stress in the pathogenesis of obesity-related inflammation in human adipose tissue</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Diabetes
ISSN
0012-1797
e-ISSN
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Volume of the periodical
62
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
1990-1995
UT code for WoS article
000319845000028
EID of the result in the Scopus database
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