Caspase-2 and JNK activated by saturated fatty acids are not involved in apoptosis induction but modulate ER stress in human pancreatic ?-cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F13%3A43907087" target="_blank" >RIV/00216208:11120/13:43907087 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1159/000343367" target="_blank" >http://dx.doi.org/10.1159/000343367</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1159/000343367" target="_blank" >10.1159/000343367</a>
Alternative languages
Result language
angličtina
Original language name
Caspase-2 and JNK activated by saturated fatty acids are not involved in apoptosis induction but modulate ER stress in human pancreatic ?-cells
Original language description
Background: Fatty acid-induced apoptosis and ER stress of pancreatic ?-cells contribute to the development of type 2 diabetes, however, the molecular mechanisms involved are unclear. Aims: In this study we have tested the role of caspase-2 and suggestedER stress mediator JNK in saturated fatty acid-induced apoptosis of the human pancreatic ?-cells NES2Y. Results: We found that stearic acid at apoptosis-inducing concentration activated ER stress signaling pathways, i.e. IRE1?, PERK and ATF6 pathways, inNES2Y cells. During stearic acid-induced apoptosis, JNK inhibition did not decrease the rate of apoptosis nor the activation of caspase-8, -9, -7 and -2 and PARP cleavage. In addition, inhibition of JNK activity did not affect CHOP expression although it did decrease the induction of BiP expression after stearic acid treatment. Caspase-2 silencing had no effect on PARP as well as caspase-8, -9 and -7 cleavage and the induction of CHOP expression, however, it also decreased the induction
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cellular Physiology and Biochemistry
ISSN
1015-8987
e-ISSN
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Volume of the periodical
31
Issue of the periodical within the volume
2-3
Country of publishing house
CH - SWITZERLAND
Number of pages
13
Pages from-to
277-289
UT code for WoS article
000318411800009
EID of the result in the Scopus database
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