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Caspase-2 and JNK activated by saturated fatty acids are not involved in apoptosis induction but modulate ER stress in human pancreatic ?-cells

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F13%3A43907087" target="_blank" >RIV/00216208:11120/13:43907087 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1159/000343367" target="_blank" >http://dx.doi.org/10.1159/000343367</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1159/000343367" target="_blank" >10.1159/000343367</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Caspase-2 and JNK activated by saturated fatty acids are not involved in apoptosis induction but modulate ER stress in human pancreatic ?-cells

  • Original language description

    Background: Fatty acid-induced apoptosis and ER stress of pancreatic ?-cells contribute to the development of type 2 diabetes, however, the molecular mechanisms involved are unclear. Aims: In this study we have tested the role of caspase-2 and suggestedER stress mediator JNK in saturated fatty acid-induced apoptosis of the human pancreatic ?-cells NES2Y. Results: We found that stearic acid at apoptosis-inducing concentration activated ER stress signaling pathways, i.e. IRE1?, PERK and ATF6 pathways, inNES2Y cells. During stearic acid-induced apoptosis, JNK inhibition did not decrease the rate of apoptosis nor the activation of caspase-8, -9, -7 and -2 and PARP cleavage. In addition, inhibition of JNK activity did not affect CHOP expression although it did decrease the induction of BiP expression after stearic acid treatment. Caspase-2 silencing had no effect on PARP as well as caspase-8, -9 and -7 cleavage and the induction of CHOP expression, however, it also decreased the induction

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FB - Endocrinology, diabetology, metabolism, nutrition

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2013

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Cellular Physiology and Biochemistry

  • ISSN

    1015-8987

  • e-ISSN

  • Volume of the periodical

    31

  • Issue of the periodical within the volume

    2-3

  • Country of publishing house

    CH - SWITZERLAND

  • Number of pages

    13

  • Pages from-to

    277-289

  • UT code for WoS article

    000318411800009

  • EID of the result in the Scopus database