Dubin-Johnson syndrome coinciding with colon cancer and atherosclerosis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F13%3A43907185" target="_blank" >RIV/00216208:11120/13:43907185 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/13:10193303 RIV/00023001:_____/13:00058656 RIV/00064165:_____/13:10193303
Result on the web
<a href="http://dx.doi.org/10.3748/wjg.v19.i6.946" target="_blank" >http://dx.doi.org/10.3748/wjg.v19.i6.946</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3748/wjg.v19.i6.946" target="_blank" >10.3748/wjg.v19.i6.946</a>
Alternative languages
Result language
angličtina
Original language name
Dubin-Johnson syndrome coinciding with colon cancer and atherosclerosis
Original language description
Hyperbilirubinemia has been presumed to prevent the process of atherogenesis and cancerogenesis mainly by decreasing oxidative stress. Dubin-Johnson syndrome is a rare, autosomal recessive, inherited disorder characterized by biphasic, predominantly conjugated hyperbilirubinemia with no progression to end-stage liver disease. The molecular basis in Dubin-Johnson syndrome is absence or deficiency of human canalicular multispecific organic anion transporter MRP2/cMOAT caused by homozygous or compound heterozygous mutation(s) in ABCC2 located on chromosome 10q24. Clinical onset of the syndrome is most often seen in the late teens or early adulthood. In this report, we describe a case of previously unrecognized Dubin-Johnson syndrome caused by two novel pathogenic mutations (c.2360_2366delCCCTGTC and c.3258+1G>A), coinciding with cholestatic liver disease in an 82-year-old male patient. The patient, suffering from advanced atherosclerosis with serious involvement of coronary arteries, deve
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FE - Other fields of internal medicine
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
World Journal of Gastroenterology
ISSN
1007-9327
e-ISSN
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Volume of the periodical
19
Issue of the periodical within the volume
6
Country of publishing house
CN - CHINA
Number of pages
5
Pages from-to
946-950
UT code for WoS article
000314578100021
EID of the result in the Scopus database
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