The Effect of Immunosuppression on Manifestations of Sepsis in an Animal Model of Cecal Ligation and Puncture
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F13%3A43907252" target="_blank" >RIV/00216208:11120/13:43907252 - isvavai.cz</a>
Alternative codes found
RIV/00064173:_____/13:#0000351 RIV/00023001:_____/13:00058480
Result on the web
<a href="http://dx.doi.org/10.1016/j.transproceed.2012.07.159" target="_blank" >http://dx.doi.org/10.1016/j.transproceed.2012.07.159</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.transproceed.2012.07.159" target="_blank" >10.1016/j.transproceed.2012.07.159</a>
Alternative languages
Result language
angličtina
Original language name
The Effect of Immunosuppression on Manifestations of Sepsis in an Animal Model of Cecal Ligation and Puncture
Original language description
The diagnosis of sepsis is difficult in immunocompromised patients owing to their modified response to infection. Our experiment in minipigs was designed to compare responses to sepsis between experimental groups of septic minipigs with and without immunosuppression. Minipigs with identical baseline parameters were randomized into 3 groups. All CLP animals developed septic shock with a febrile response, tachycardia, and hypotension requiring noradrenaline administration. The hemodynamic responses to sepsis in septic groups with and without immunosuppression were similar. Noradrenaline infusion was started on average later in the immunosuppression than in the group without immunosuppression; however, the difference was not significant. The kinetics of the plasma levels of most selected cytokines and C-reactive protein were similar in both septic groups. All CLP animals developed sepsis within 24 hours on average. Significant differences in IL-6 and IL-10 plasma levels were recorded betw
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NS10556" target="_blank" >NS10556: The effect of immunosuppression on immunopathologic alterations in an animal model of sepsis</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Transplantation Proceedings
ISSN
0041-1345
e-ISSN
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Volume of the periodical
45
Issue of the periodical within the volume
2
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
8
Pages from-to
770-777
UT code for WoS article
000316772500052
EID of the result in the Scopus database
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