The expression profile of ATP-binding cassette transporter genes in breast carcinoma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F13%3A43907351" target="_blank" >RIV/00216208:11120/13:43907351 - isvavai.cz</a>
Alternative codes found
RIV/75010330:_____/13:00010096 RIV/00098892:_____/13:#0000614
Result on the web
<a href="http://dx.doi.org/10.2217/PGS.13.26" target="_blank" >http://dx.doi.org/10.2217/PGS.13.26</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2217/PGS.13.26" target="_blank" >10.2217/PGS.13.26</a>
Alternative languages
Result language
angličtina
Original language name
The expression profile of ATP-binding cassette transporter genes in breast carcinoma
Original language description
Aim: ATP-binding cassette (ABC) transporters contribute to development of resistance to anticancer drugs via ATP-dependent drug efflux. A major goal of our study was to investigate associations between the expression of ABC transporters and outcome of breast carcinoma patients. Patients & methods: Transcript levels of all 49 human ABC transporters were determined in post-treatment tumor and non-neoplastic tissue samples from 68 breast carcinoma patients treated by neoadjuvant chemotherapy. Six ABC transporters were then evaluated in independent series of 100 pretreatment patients. Results: ABCA5/6/8/9/10, ABCB1/5/11, ABCC6/9, ABCD2/4, ABCG5 and ABCG8 were significantly downregulated and ABCA2/3/7/12, ABCB2/3/8/9/10, ABCC1/4/5/10/11/12, ABCD1/3, ABCE1,ABCF1/2/3 and ABCG1 were upregulated in post-treatment tumors compared with non-neoplastic tissues. Significant associations of intratumoral levels of ABCC1 and ABCC8 with grade and expression of hormonal receptors were found in both sets
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pharmacogenomics
ISSN
1462-2416
e-ISSN
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Volume of the periodical
14
Issue of the periodical within the volume
5
Country of publishing house
GB - UNITED KINGDOM
Number of pages
15
Pages from-to
515-529
UT code for WoS article
000317177700016
EID of the result in the Scopus database
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