Pharmacodynamic Effect of Clopidogrel in Patients Undergoing Transcatheter Aortic Valve Implantation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F13%3A43907560" target="_blank" >RIV/00216208:11120/13:43907560 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1155/2013/386074" target="_blank" >http://dx.doi.org/10.1155/2013/386074</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2013/386074" target="_blank" >10.1155/2013/386074</a>
Alternative languages
Result language
angličtina
Original language name
Pharmacodynamic Effect of Clopidogrel in Patients Undergoing Transcatheter Aortic Valve Implantation
Original language description
The aim of this study was to analyze periprocedural and mid-term effect of clopidogrel on platelet function using the VerifyNow P2Y(12) point-of-care assay in patients undergoing TAVI. Platelet reactivity was measured at the beginning of the procedure after 300 mg clopidogrel bolus administration and during the follow-up (at 1 month after the procedure) in 52 patients undergoing TAVI using the Medtronic CoreValve prosthesis (Medtronic CoreValve). A cutoff value of 240 PRU was used to identify nonresponders to clopidogrel treatment with high residual platelet reactivity (HRPR). Baseline HRPR was identified in 80% of patients and in 72% of patients during 6-month follow-up. There was no significant difference in the pharmacodynamic effects of clopidogrelon platelet reactivity from baseline to 6-months follow-up (297 +/- 57 vs. 275 +/- 62; P = 0.058). Ischemic event occurred only in 3 patients (5.8%) from the study group. In conclusion, majority of patients undergoing TAVI had high resid
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EI - Biotechnology and bionics
OECD FORD branch
—
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BioMed Research International
ISSN
2314-6133
e-ISSN
—
Volume of the periodical
-
Issue of the periodical within the volume
Article ID 386074
Country of publishing house
US - UNITED STATES
Number of pages
3
Pages from-to
1-3
UT code for WoS article
000322479300001
EID of the result in the Scopus database
—