New insights in bilirubin metabolism and their clinical implications

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F13%3A43907675" target="_blank" >RIV/00216208:11120/13:43907675 - isvavai.cz</a>

Alternative codes found

RIV/00023001:_____/13:00058730

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

New insights in bilirubin metabolism and their clinical implications

Original language description

Bilirubin, a major end product of heme breakdown, is an important constituent of bile, responsible for its characteristic colour. Over recent decades, our understanding of bilirubin metabolism has expanded along with the processes of elimination of otherendogenous and exogenous anionic substrates, mediated by the action of multiple transport systems at the sinusoidal and canalicular membrane of hepatocytes. Several inherited disorders characterised by impaired bilirubin conjugation (Crigler-Najjar syndrome type. and type., Gilbert syndrome) or transport (Dubin-Johnson and Rotor syndrome) result in various degrees of hyperbilirubinemia of either the predominantly unconjugated or predominantly conjugated type. Moreover, disrupted regulation of hepatobiliary transport systems can explain jaundice in many acquired liver disorders. In this review, we discuss the recent data on liver bilirubin handling based on the discovery of the molecular basis of Rotor syndrome. The data show that a sub

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

World Journal of Gastroenterology

ISSN

1007-9327

e-ISSN

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Volume of the periodical

19

Issue of the periodical within the volume

38

Country of publishing house

CN - CHINA

Number of pages

10

Pages from-to

6398-6407

UT code for WoS article

000325540300010

EID of the result in the Scopus database

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