Expression of steroid receptor coactivator 3 in ovarian epithelial cancer is a poor prognostic factor and a marker for platinum resistance

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F13%3A43908110" target="_blank" >RIV/00216208:11120/13:43908110 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1038/bjc.2013.199" target="_blank" >http://dx.doi.org/10.1038/bjc.2013.199</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/bjc.2013.199" target="_blank" >10.1038/bjc.2013.199</a>

Result language

angličtina

Original language name

Expression of steroid receptor coactivator 3 in ovarian epithelial cancer is a poor prognostic factor and a marker for platinum resistance

Original language description

Steroid receptor coactivator 3 (SRC3) is an important coactivator of a number of transcription factors and is associated with a poor outcome in numerous tumours. Steroid receptor coactivator 3 is amplified in 25% of epithelial ovarian cancers (EOCs) andits expression is higher in EOCs compared with non-malignant tissue. No data is currently available with regard to the expression of SRC-3 in EOC and its influence on outcome or the efficacy of treatment. METHODS: Immunohistochemistry was performed for SRC3, oestrogen receptor-?, HER2, PAX2 and PAR6, and protein expression was quantified using automated quantitative immunofluorescence (AQUA) in 471 EOCs treated between 1991 and 2006 with cytoreductive surgery followed by first-line treatment platinum-based therapy, with or without a taxane. RESULTS: Steroid receptor coactivator 3 expression was significantly associated with advanced stage and was an independent prognostic marker. High expression of SRC3 identified patients who have a si

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

British Journal of Cancer

ISSN

0007-0920

e-ISSN

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Volume of the periodical

108

Issue of the periodical within the volume

10

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

2039-2044

UT code for WoS article

000319561300017

EID of the result in the Scopus database

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