Age-Related Differences in NMDA Receptor Subunits of Prenatally Methamphetamine-Exposed Male Rats
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F14%3A43908805" target="_blank" >RIV/00216208:11120/14:43908805 - isvavai.cz</a>
Alternative codes found
RIV/67985807:_____/14:00430525 RIV/00023752:_____/14:43914606
Result on the web
<a href="http://dx.doi.org/10.1007/s11064-014-1381-4" target="_blank" >http://dx.doi.org/10.1007/s11064-014-1381-4</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11064-014-1381-4" target="_blank" >10.1007/s11064-014-1381-4</a>
Alternative languages
Result language
angličtina
Original language name
Age-Related Differences in NMDA Receptor Subunits of Prenatally Methamphetamine-Exposed Male Rats
Original language description
There is accumulating evidence that methamphetamine (MA) is a widely abused drug popular among pregnant women. MA exposure is associated with changes in the function of neurotransmitter systems, namely the dopaminergic, serotonergic and glutamatergic systems. Since N-methyl-d-aspartate receptors (NMDA) are affected by MA-induced glutamate release, we assessed the expression of NMDAR subunits (NR1, NR2A, and NR2B) and postsynaptic density protein 95 (PSD-95), which is connected with NMDAR. We measured the expression of these proteins in adolescent (30 days old) and adult (60 days old) rat males exposed to MA during the entire prenatal period and compared them with the same parameters in age matched saline-exposed rats. There was a significant increase in the NR1 and NR2B subunits in the hippocampus of adult males, but not in adolescent males. We identified a significant change in adult MA-induced rats when compared to adult controls for NR2A and NR2B, while in adolescent MA rats this ch
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GAP303%2F10%2F0580" target="_blank" >GAP303/10/0580: What is the role of mesolimbic reward circuit in the long-term effect of prenatal methamphetamine exposure in rats?</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neurochemical Research
ISSN
0364-3190
e-ISSN
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Volume of the periodical
39
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
2040-2046
UT code for WoS article
000343293000003
EID of the result in the Scopus database
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