Chitinase 3-like 1: prognostic biomarker in clinically isolated syndromes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F15%3A43909444" target="_blank" >RIV/00216208:11120/15:43909444 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1093/brain/awv017" target="_blank" >http://dx.doi.org/10.1093/brain/awv017</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/brain/awv017" target="_blank" >10.1093/brain/awv017</a>

Result language

angličtina

Original language name

Chitinase 3-like 1: prognostic biomarker in clinically isolated syndromes

Original language description

Chitinase 3-like 1 (CHI3L1) has been proposed as a biomarker associated with the conversion to clinically definite multiple sclerosis in patients with clinically isolated syndromes, based on the finding of increased cerebrospinal fluid CHI3L1 levels in clinically isolated syndrome patients who later converted to multiple sclerosis compared to those who remained as clinically isolated syndrome. Here, we aimed to validate CHI3L1 as a prognostic biomarker in a large cohort of patients with clinically isolated syndrome. This is a longitudinal cohort study of clinically isolated syndrome patients with clinical, magnetic resonance imaging, and cerebrospinal fluid data prospectively acquired. A total of 813 cerebrospinal fluid samples from patients with clinically isolated syndrome were recruited from 15 European multiple sclerosis centres. Cerebrospinal fluid CHI3L1 levels were measured by enzyme-linked immunosorbent assay. These findings validate cerebrospinal fluid CHI3L1 as a biomarker as

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Brain

ISSN

0006-8950

e-ISSN

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Volume of the periodical

138

Issue of the periodical within the volume

4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

14

Pages from-to

918-931

UT code for WoS article

000353522100019

EID of the result in the Scopus database

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