Epinephrine-stimulated glycogen breakdown activates glycogen synthase and increases insulin-stimulated glucose uptake in epitrochlearis muscles

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F15%3A43909450" target="_blank" >RIV/00216208:11120/15:43909450 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1152/ajpendo.00282.2014" target="_blank" >http://dx.doi.org/10.1152/ajpendo.00282.2014</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1152/ajpendo.00282.2014" target="_blank" >10.1152/ajpendo.00282.2014</a>

Result language
angličtina
Original language name
Epinephrine-stimulated glycogen breakdown activates glycogen synthase and increases insulin-stimulated glucose uptake in epitrochlearis muscles
Original language description
Epinephrine increases glycogen synthase (GS) phosphorylation and decreases GS activity but also stimulates glycogen breakdown, and low glycogen content normally activates GS. To test the hypothesis that glycogen content directly regulates GS phosphorylation, glycogen breakdown was stimulated in condition with decreased GS activation. Saline or epinephrine (0.02 mg/100 g rat) was injected subcutaneously in Wistar rats (similar to 130 g) with low (24-h-fasted), normal (normal diet), and high glycogen content (fasted-refed), and epitrochlearis muscles were removed after 3 h and incubated ex vivo, eliminating epinephrine action. Epinephrine injection reduced glycogen content in epitrochlearis muscles with high (120.7 +/- 17.8 vs. 204.6 +/- 14.5 mmol/kg, P< 0.01) and normal glycogen (89.5 +/- 7.6 vs. 152 +/- 8.1 mmol/kg, P < 0.01), but not significantly in muscles with low glycogen (90.0 +/- 5.0 vs. 102.8 +/- 7.8 mmol/kg, P = 0.17). In saline-injected rats, GS phosphorylation at sites 2 +
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical
American Journal of Physiology - Endocrinology and Metabolism
ISSN
0193-1849
e-ISSN
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Volume of the periodical
308
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
"E231"-"E240"
UT code for WoS article
000349303500006
EID of the result in the Scopus database
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