Intrathecal baclofen in spinal spasticity: frequency and severity of withdrawal syndrome
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F15%3A43909578" target="_blank" >RIV/00216208:11120/15:43909578 - isvavai.cz</a>
Result on the web
<a href="http://www.painphysicianjournal.com/linkout_vw.php?issn=1533-3159&vol=18&page=E633" target="_blank" >http://www.painphysicianjournal.com/linkout_vw.php?issn=1533-3159&vol=18&page=E633</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Intrathecal baclofen in spinal spasticity: frequency and severity of withdrawal syndrome
Original language description
BACKGROUND: Intrathecal baclofen (ITB) delivered by programmable pump devices represents an important modality for long-term treatment of severe spinal spasticity. OBJECTIVE: One of the serious adverse events is a withdrawal syndrome after sudden interruption of ITB delivery. In this study, we analyzed the frequency and severity of this complication. Treatment recommendations follow. METHODS: A total of 54 ITB pumps were successfully implanted in 39 patients with severe intractable spasticity (24 with spinal cord injury, 15 with multiple sclerosis, 24 men, age range 21 - 59 years). RESULTS: Eight patients developed a withdrawal syndrome on total a daily dose of ITB between 90 - 420 ?g/day. Seven patients had catheter-related complications. In one patient, pump failure was observed due to its corrosion. Within the group, baclofen withdrawal syndrome occurred once in 20.1 pump-years counted out of 160.4 pump-years of ITB treatment. CONCLUSIONS: ITB withdrawal syndrome is a rare but life-
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pain Physician
ISSN
1533-3159
e-ISSN
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Volume of the periodical
18
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
"E633"-"E641"
UT code for WoS article
000358900300010
EID of the result in the Scopus database
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