Expected outcomes from topical haemoglobin spray in non-healing and worsening venous leg ulcers

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F15%3A43909875" target="_blank" >RIV/00216208:11120/15:43909875 - isvavai.cz</a>

Alternative codes found

RIV/00064173:_____/15:#0000496

Result on the web

<a href="http://dx.doi.org/10.12968/jowc.2015.24.5.228" target="_blank" >http://dx.doi.org/10.12968/jowc.2015.24.5.228</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.12968/jowc.2015.24.5.228" target="_blank" >10.12968/jowc.2015.24.5.228</a>

Result language

angličtina

Original language name

Expected outcomes from topical haemoglobin spray in non-healing and worsening venous leg ulcers

Original language description

Objective: To evaluate the effect of topical haemoglobin spray on treatment response and wound-closure rates in patients with chronic venous leg ulcers. Method: A linear regression model was used to forecast healing outcomes over a 12-month period. Simulated data were taken from normal distributions based on post-hoc analysis of a 72-patient study in non-healing and worsening wounds (36 patients receiving standard care and 36 receiving standard care plus topical haemoglobin spray). Using a simulated 25,000 'patients' from each group, the proportion of wound closure over time was projected. Results: Simulation results predicted a 55% wound closure rate at six months in the haemoglobin group, compared with 4% in the standard care group. Over a 12-month simulation period, a 43% overall reduction in wound burden was predicted. With the haemoglobin spray, 85% of wounds were expected to heal in 12 months, compared with 13% in the standard care group. Conclusion: Topical haemoglobin spray promises a more effective treatment for chronic venous leg ulcers than standard care alone in wounds that are non-healing or worsening. Further research is required to validate these predictions and to identify achievable outcomes in other chronic wound types.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FO - Dermatology and venereology

OECD FORD branch

—

Project

—

Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Wound Care

ISSN

0969-0700

e-ISSN

—

Volume of the periodical

24

Issue of the periodical within the volume

5

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

228-236

UT code for WoS article

000355762400006

EID of the result in the Scopus database

2-s2.0-84929325697