A pain-mediated neural signal induces relapse in murine autoimmune encephalomyelitis, a multiple sclerosis model
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F15%3A43913127" target="_blank" >RIV/00216208:11120/15:43913127 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.7554/eLife.08733" target="_blank" >http://dx.doi.org/10.7554/eLife.08733</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.7554/eLife.08733" target="_blank" >10.7554/eLife.08733</a>
Alternative languages
Result language
angličtina
Original language name
A pain-mediated neural signal induces relapse in murine autoimmune encephalomyelitis, a multiple sclerosis model
Original language description
Although pain is a common symptom of various diseases and disorders, its contribution to disease pathogenesis is not well understood. Here we show using murine experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis (MS), that pain induces EAE relapse. Mechanistic analysis showed that pain induction activates a sensory-sympathetic signal followed by a chemokine-mediated accumulation of MHC class II+CD11b+ cells that showed antigen-presentation activity at specific ventral vessels in the fifth lumbar cord of EAE-recovered mice. Following this accumulation, various immune cells including pathogenic CD4+ T cells recruited in the spinal cord in a manner dependent on a local chemokine inducer in endothelial cells, resulting in EAE relapse. Our results demonstrate that a pain-mediated neural signal can be transformed into an inflammation reaction at specific vessels to induce disease relapse, thus making this signal a potential therapeutic target.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
eLife
ISSN
2050-084X
e-ISSN
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Volume of the periodical
4
Issue of the periodical within the volume
August
Country of publishing house
GB - UNITED KINGDOM
Number of pages
23
Pages from-to
"e08733"
UT code for WoS article
000373443800001
EID of the result in the Scopus database
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