Naïve T Cell Homeostasis Regulated by Stress Responses and TCR Signaling

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F15%3A43913129" target="_blank" >RIV/00216208:11120/15:43913129 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3389/fimmu.2015.00638" target="_blank" >http://dx.doi.org/10.3389/fimmu.2015.00638</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fimmu.2015.00638" target="_blank" >10.3389/fimmu.2015.00638</a>

Result language
angličtina
Original language name
Naïve T Cell Homeostasis Regulated by Stress Responses and TCR Signaling
Original language description
The survival of naïve T cells is believed to require signals from TCR-pMHC interactions and cytokines such as IL-7. In contrast, signals that negatively impact naïve T cell survival are less understood. We conducted a forward genetic screening of mice and found a mutant mouse line with reduced number of naïve T cells (T-Red mice). T-Red mice have a point mutation in the Kdelr1 gene, and their naïve T cells show enhanced integrated stress response (ISR), which eventually induces their apoptosis. Therefore, naïve T cells require a KDEL receptor-mediated mechanism that efficiently relieves cellular stress for their survival in vivo. Interestingly, naïve T cells expressing TCR with higher affinity/avidity to self-antigens survive in T-Red mice, suggesting the possible link between TCR-mediated survival and ISR-induced apoptosis. In this article, we discuss the regulation of naïve T cell homeostasis, keeping special attention on the ISR and TCR signal.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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