Procalcitonin is more likely to be released by the fetus rather than placental tissue during chorioamnionitis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F16%3A43911777" target="_blank" >RIV/00216208:11120/16:43911777 - isvavai.cz</a>
Alternative codes found
RIV/00023698:_____/16:N0000003
Result on the web
<a href="http://dx.doi.org/10.5507/bp.2016.041" target="_blank" >http://dx.doi.org/10.5507/bp.2016.041</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5507/bp.2016.041" target="_blank" >10.5507/bp.2016.041</a>
Alternative languages
Result language
angličtina
Original language name
Procalcitonin is more likely to be released by the fetus rather than placental tissue during chorioamnionitis
Original language description
AIMS: To analyze the relationship between maternal, cord blood and neonatal procalcitonin (PCT) levels in preterm deliveries with and without histologically proven chorioamnionitis (HCA). METHODS: 91 mother-infant pairs from 24+0 to 33+0 gestational weeks were analyzed. Procalcitonin was measured in all mothers within 24 hours before and subsequently in cord blood and in neonates within the first two hours after delivery. PCT levels were analysed in relationship to HCA and clinical outcome. RESULTS: HCA was confirmed in 28 cases (31%). We found no differences in PCT values between HCA positive and negative groups in maternal blood (0.1+-0.1 vs 0.09+-0.09 ng/L, P = 0.76). PCT values in cord blood and neonates were significantly higher in the HCA positive compared to HCA negative group (0.23+-0.1 vs 1.2+-2.7 ng/L, P < 0.001 and 0.89+-3.4 vs 4.2+-9.3 ng/L, P < 0.0001 respectively). PCT values in neonates were significantly higher than those of cord blood. Levels were not influenced by the mode of delivery, gestational age or premature rupture of membranes. Chorioamnionitis was more frequently associated with early onset neonatal sepsis (36% in HCA group vs 5% in non HCA group, P < 0.0001). Comparison of other clinical data revealed no differences between HCA positive and negative groups. CONCLUSION: This study showed higher PCT in cord and neonatal blood in the presence of proven histological chorioamnionitis. The measurement of PCT in mothers' blood is not helpful for diagnosis of HCA. The changes in PCT values shown suggest its production and release by fetal tissue.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomedical Papers
ISSN
1213-8118
e-ISSN
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Volume of the periodical
160
Issue of the periodical within the volume
4
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
4
Pages from-to
499-502
UT code for WoS article
000392810500007
EID of the result in the Scopus database
2-s2.0-85006274179