Kinase Signaling in Apoptosis Induced by Saturated Fatty Acids in Pancreatic β-Cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F16%3A43912207" target="_blank" >RIV/00216208:11120/16:43912207 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3390/ijms17091400" target="_blank" >http://dx.doi.org/10.3390/ijms17091400</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms17091400" target="_blank" >10.3390/ijms17091400</a>
Alternative languages
Result language
angličtina
Original language name
Kinase Signaling in Apoptosis Induced by Saturated Fatty Acids in Pancreatic β-Cells
Original language description
Pancreatic β-cell failure and death is considered to be one of the main factors responsible for type 2 diabetes. It is caused by, in addition to hyperglycemia, chronic exposure to increased concentrations of fatty acids, mainly saturated fatty acids. Molecular mechanisms of apoptosis induction by saturated fatty acids in β-cells are not completely clear. It has been proposed that kinase signaling could be involved, particularly, c-Jun N-terminal kinase (JNK), protein kinase C (PKC), p38 mitogen-activated protein kinase (p38 MAPK), extracellular signal-regulated kinase (ERK), and Akt kinases and their pathways. In this review, we discuss these kinases and their signaling pathways with respect to their possible role in apoptosis induction by saturated fatty acids in pancreatic β-cells.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GP14-00630P" target="_blank" >GP14-00630P: Regulation of apoptosis induction by saturated and unsaturated fatty acids in pancreatic beta-cells: a proteomic approach</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Molecular Sciences
ISSN
1422-0067
e-ISSN
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Volume of the periodical
17
Issue of the periodical within the volume
9
Country of publishing house
CH - SWITZERLAND
Number of pages
15
Pages from-to
"Article 1400"
UT code for WoS article
000385525500028
EID of the result in the Scopus database
2-s2.0-84987755635