Comparison of early (2 days) and later (28 days) response of adipose tissue to very-low calorie diet in obese women
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F16%3A43912251" target="_blank" >RIV/00216208:11120/16:43912251 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1210/jc.2016-2161" target="_blank" >http://dx.doi.org/10.1210/jc.2016-2161</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1210/jc.2016-2161" target="_blank" >10.1210/jc.2016-2161</a>
Alternative languages
Result language
angličtina
Original language name
Comparison of early (2 days) and later (28 days) response of adipose tissue to very-low calorie diet in obese women
Original language description
CONTEXT: Beneficial metabolic effects of calorie restriction found in the early stage of hypocalorie diets may be caused by the modulation of metabolic and endocrine function of adipose tissue. OBJECTIVE: To compare metabolic and inflammation-related characteristics of subcutaneous adipose tissue (SAAT) in the early (2 days) and later (28 days) phase of VLCD. Design, Setting, Intervention and Patients: 17 moderately obese premenopausal women followed 800 kcal/d VLCD for 28 days. Anthropometric measurements, blood sampling and biopsy of SAAT were performed before diet and after 2 and 28 days of VLCD. MAIN OUTCOME MEASURE(S): mRNA expression of 50 genes related to lipid metabolism, inflammation, and fibrosis were analyzed in SAAT. Secretion of adipokines was determined in SAAT explants and adipokines, FGF21 and CRP were measured in plasma. RESULTS: In the early phase of VLCD expression of lipolytic genes was increased while expression of lipogenic genes was significantly suppressed. The inflammatory markers in SAAT remained unchanged. At the later phase, expression of genes involved in lipogenesis and β-oxidation was markedly suppressed, while expression of inflammatory markers was increased. The changes of lipogenic genes after 28 days of VLCD correlated with FGF21 changes. CONCLUSION: The early and later phases of VLCD differ in respect to metabolic and inflammatory responses in SAAT. The expression changes in SAAT in the early phase of VLCD could not explain the effect of short calorie restriction on the improvement of insulin sensitivity. An interplay of SAAT with liver function during VLCD mediated by FGF21 might be suggested.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
The Journal of Clinical Endocrinology & Metabolism
ISSN
0021-972X
e-ISSN
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Volume of the periodical
101
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
5021-5029
UT code for WoS article
000390951000058
EID of the result in the Scopus database
2-s2.0-85003480081