Can anxiety tested in the Elevated Plus Maze be related to nociception sensitivity in adult male rats?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F16%3A43912349" target="_blank" >RIV/00216208:11120/16:43912349 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.14712/23362936.2016.19" target="_blank" >http://dx.doi.org/10.14712/23362936.2016.19</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14712/23362936.2016.19" target="_blank" >10.14712/23362936.2016.19</a>

Result language

angličtina

Original language name

Can anxiety tested in the Elevated Plus Maze be related to nociception sensitivity in adult male rats?

Original language description

Methamphetamine (MA) is one of the most addictive psychostimulant drugs with a high potential for abuse. Our previous studies demonstrated that MA administered to pregnant rats increases pain sensitivity and anxiety in their adult offspring and makes them more sensitive to acute administration of the same drug in adulthood. Because individuals can differ considerably in terms of behavior and physiology, such as rats that do not belong in some characteristics (e.g. anxiety) to average (the most often incidence), can be described as Low-responders or High-responders, are then more or less sensitive to pain. Therefore, prenatally MA-exposed adult male rats treated in adulthood with a single dose of MA (1 mg/ml/kg) or saline (1 ml/kg) were tested in the present study. We examined the effect of acute MA treatment on: (1) the anxiety in the Elevated Plus-Maze (EPM) test and memory in EPM re-test; (2) nociception sensitivity in the Plantar test; (3) the correlation between the anxiety, memory and the nociception. Our results demonstrate that (1) MA has an anxiogenic effect on animals prenatally exposed to the same drug in the EPM; (2) all the differences induced by acute MA treatment disappeared within the time of 48 hours; (3) there was no effect of MA on nociception per se, but MA induced higher anxiety in individuals less sensitive to pain than in animals more sensitive to pain. In conclusion, the present study shows unique data showing correlation between anxiety and nociceptive sensitivity of prenatally MA-exposed rats that is induced by acute drug administration.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Prague Medical Report

ISSN

1214-6994

e-ISSN

—

Volume of the periodical

117

Issue of the periodical within the volume

4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

13

Pages from-to

185-197

UT code for WoS article

—

EID of the result in the Scopus database

—