Invasive Hemodynamic Assessment of Cardiac Output State after MitraClip Therapy in Nonanaesthetized Patients with Functional Mitral Regurgitation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F16%3A43912752" target="_blank" >RIV/00216208:11120/16:43912752 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1155/2016/6296972" target="_blank" >http://dx.doi.org/10.1155/2016/6296972</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2016/6296972" target="_blank" >10.1155/2016/6296972</a>
Alternative languages
Result language
angličtina
Original language name
Invasive Hemodynamic Assessment of Cardiac Output State after MitraClip Therapy in Nonanaesthetized Patients with Functional Mitral Regurgitation
Original language description
Background. Surgical correction of mitral regurgitation (MR) can lead to postoperative low cardiac output state. We aimed to assess the acute hemodynamic changes after percutaneous MitraClip therapy (a unique model without influence of factors linked to surgical procedure) in patients with functional MR without the influence of general anaesthesia. Methods. We studied invasive hemodynamic parameters in 23 patients before procedure (conscious, nonsedated patients), during procedure (intubated patients), and the first day after MitraClip implantation (conscious, extubated patients). Results. Mitral valve clipping significantly increased cardiac index (CI) (from 2.0 +- 0.5 to 3.3 +- 0.6 L/min/m(2); p < 0.01). Conversely, there was significant reduction in the mean pulmonary capillary wedge pressure (PCWP) (from 18.6 +- 5.7 to 10.5 +- 3.8 mmHg; p < 0.01), mean pulmonary artery pressure (from 29.8 +- 10.9 to 25.2 +- 10.3 mmHg; p = 0.03), and pulmonary vascular resistance index (from 531 +- 359 to 365 +- 193 dyn.s.cm(-5)/m(2); p = 0.03). Conclusions. The functional MR therapy with percutaneous MitraClip device results in significant increase in CI (+66%) and concomitant decrease in PCWP (-42%). None of our patients developed low cardiac output state. Our results support the idea that significant part of low cardiac output state after cardiac surgery is due to surgery related factors rather than due to increase in afterload after MR elimination.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EI - Biotechnology and bionics
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BioMed Research International
ISSN
2314-6133
e-ISSN
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Volume of the periodical
2016
Issue of the periodical within the volume
November
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
"Article 6296972"
UT code for WoS article
000390533100001
EID of the result in the Scopus database
2-s2.0-85008958256