A comparison of age-related changes in axial prestretch in human carotid arteries and in human abdominal aorta

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F17%3A43911612" target="_blank" >RIV/00216208:11120/17:43911612 - isvavai.cz</a>

Alternative codes found

RIV/68407700:21220/17:00315920

Result on the web

<a href="http://dx.doi.org/10.1007/s10237-016-0797-y" target="_blank" >http://dx.doi.org/10.1007/s10237-016-0797-y</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10237-016-0797-y" target="_blank" >10.1007/s10237-016-0797-y</a>

Result language

angličtina

Original language name

A comparison of age-related changes in axial prestretch in human carotid arteries and in human abdominal aorta

Original language description

It is known that large arteries in situ are subjected to significant axial prestretch. This prestretch plays an important physiological role in optimizing the biomechanical response of an artery. It is also known that the prestretch declines with age. However, a detailed description of age-related changes in prestretch is available only for the abdominal aorta and for the femoropliteal artery. Our study presents results of measurements of axial prestretch in 229 left common carotid arteries excised in autopsies. It was found that the prestretch of the carotid artery correlates significantly with age ([Formula: see text], p value &lt; 0.001). A linear regression model was used to fit the observations. Simultaneously with the measurement of the prestretch in the carotid artery, the axial prestretch was also measured in abdominal aorta. By comparing data obtained from these locations, it was concluded that the axial prestretch in the carotid artery is greater than in the abdominal aorta, and that atherosclerosis develops more rapidly in the abdominal aorta than in the carotid artery. Histological sections obtained from 8 carotid arteries and aortas suggest that the medial layer of the left common carotid artery is significantly thinner than aortic media (median/IQR: 0.343/0.086 vs. 0.482/0.172 mm, [Formula: see text] in Wilcoxon signed-rank test) and simultaneously that carotid media contains a lower number of elastic membranes (median/IQR: 26.5/11.8 vs. 31.5/11.8, [Formula: see text] in the Wilcoxon signed-rank test). This could be a reason for the different extent of the prestretch observed in aorta and in carotid artery. Our data sample also contains 5 measurements of the axial prestretch in abdominal aortas suffering from an aneurysm. It was found that aneurysmatic aortas also exhibit axial retraction when excised from in situ position. To the best of our knowledge, this is the first time that detailed data characterizing axial prestretch of the human left common carotid artery have been presented.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

20601 - Medical engineering

Project

<a href="/en/project/NV15-27941A" target="_blank" >NV15-27941A: The use of nonatigen fish collagen in construction of implants and as drug carriers.</a><br>

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomechanics and Modeling in Mechanobiology

ISSN

1617-7959

e-ISSN

—

Volume of the periodical

16

Issue of the periodical within the volume

1

Country of publishing house

DE - GERMANY

Number of pages

9

Pages from-to

375-383

UT code for WoS article

000394153400026

EID of the result in the Scopus database

2-s2.0-84969170252