Gadolinium contrast agents - are they really safe?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F17%3A43913120" target="_blank" >RIV/00216208:11120/17:43913120 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/17:10359061 RIV/00064173:_____/17:N0000038
Result on the web
<a href="http://dx.doi.org/10.5301/jva.5000713" target="_blank" >http://dx.doi.org/10.5301/jva.5000713</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5301/jva.5000713" target="_blank" >10.5301/jva.5000713</a>
Alternative languages
Result language
angličtina
Original language name
Gadolinium contrast agents - are they really safe?
Original language description
Gadolinium-based contrast agents (GBCA) are used worldwide for enhanced MRI examinations, including heart and vessels. Gadolinium is a highly toxic heavy metal. If used in GBCA it must be tightly bound to ligands. The configuration of ligands influences the stability of the GBCA and two types of chelates have been used. Macrocyclic chelates offer better protection and binding of gadolinium ion than linear chelates with a flexible open chain - gadolinium could be easier released from the latter ones. GBCAs are excreted from the body mostly by the kidneys, which is of importance in chronic kidney disease.Two states are related to gadolinium: nephrogenic systemic fibrosis (NSF) and gadolinium body storage. NSF is a severe and debilitating disease, directly connected to gadolinium toxicity, proven after the use of linear chelates. Due to strict recommendations of radiology societies, NSF was practically eradicated. Gadolinium deposition was observed especially in bones and in some brain areas: in dentate nucleus and in globus pallidus, even years after the GBCA administration. The form of the storage (chelated or free), as well as their clinical impact, are not clear, but first observations of "gadolinium deposition disease" have been reported.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30224 - Radiology, nuclear medicine and medical imaging
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
The Journal of Vascular Access
ISSN
1129-7298
e-ISSN
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Volume of the periodical
18
Issue of the periodical within the volume
Suppl. 2
Country of publishing house
IT - ITALY
Number of pages
7
Pages from-to
"S1"-"S7"
UT code for WoS article
000399094300001
EID of the result in the Scopus database
2-s2.0-85019036925