Sex differences in the strategies of spatial learning in prenatally-exposed rats treated with various drugs in adulthood

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F17%3A43913158" target="_blank" >RIV/00216208:11120/17:43913158 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.bbr.2017.03.041" target="_blank" >http://dx.doi.org/10.1016/j.bbr.2017.03.041</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bbr.2017.03.041" target="_blank" >10.1016/j.bbr.2017.03.041</a>

Result language

angličtina

Original language name

Sex differences in the strategies of spatial learning in prenatally-exposed rats treated with various drugs in adulthood

Original language description

In the present study we investigated the sex differences in the effect of adult long-term drug treatment on cognitive functions of Wistar rats, which were prenatally exposed to MA (5 mg/kg) or saline. Cognitive functions were tested as an ability of spatial learning in the Morris Water Maze (MWM), which consisted of three types of tests&quot;Place Navigation Test&quot;; &quot;Probe Test&quot;, and &quot;Memory Recall Test&quot;. Adult animals were injected daily, after completion of the last trial, either with saline or cocaine (COC; 5 mg/kg), MDMA (3,4-methylenedioxy-methamphetamine; 5 mg/kg), morphine (MOR; 5 mg/kg), or delta-9-tetrahydrocannabinol (THC; 2 mg/kg). Results revealed worsened MWM performance in female rats after drug treatment in adulthood. Not only were traditionally investigated parameters affected by drug treatment (latency of platform acquisition, search strategy, distance traveled), but also strategies used by animals (thigmotaxis, scanning). Analyses of search strategies observed in the Place Navigation Test, as well as in the Memory Recall Test, demonstrated variations in the percentage of time spent in thigmotaxis and scanning in females after treatment with COC, MDMA, MOR, and THC. Although we did not see a sensitizing effect of prenatal MA, in some cases the effect of drug treatment in adulthood differed depending on the prenatal drug exposure. The data presented in this study demonstrates that exposure to drugs with various mechanisms of action alters spatial abilities of female rats in the MWM. Alterations in the effect of adult drug treatment with reference to prenatal drug exposure were also found in the present study.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

<a href="/en/project/GA14-03708S" target="_blank" >GA14-03708S: Determination of critical developmental period for methamphetamine effects in rats</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Behavioural Brain Research

ISSN

0166-4328

e-ISSN

—

Volume of the periodical

327

Issue of the periodical within the volume

June

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

11

Pages from-to

83-93

UT code for WoS article

000401678500010

EID of the result in the Scopus database

2-s2.0-85016490959