Increased Incretin But Not Insulin Response after Oral versus Intravenous Branched Chain Amino Acids

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F17%3A43913343" target="_blank" >RIV/00216208:11120/17:43913343 - isvavai.cz</a>

Alternative codes found

RIV/00064173:_____/17:N0000105

Result on the web

<a href="http://dx.doi.org/10.1159/000475604" target="_blank" >http://dx.doi.org/10.1159/000475604</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000475604" target="_blank" >10.1159/000475604</a>

Result language

angličtina

Original language name

Increased Incretin But Not Insulin Response after Oral versus Intravenous Branched Chain Amino Acids

Original language description

Background/Aims: Branched chain amino acids (BCAAs) are known to exert an insulinotropic effect. Whether this effect is mediated by incretins (glucagon like peptide 1 [GLP-1] or glucose-dependent insulinotropic peptide [GIP]) is not known. The aim of this study was to show whether an equivalent dose of BCAA elicits a greater insulin and incretin response when administered orally than intravenously (IV). Methods: Eighteen healthy, male subjects participated in 3 tests: IV application of BCAA solution, oral ingestion of BCAA and placebo in an equivalent dose (30.7 +- 1.1 g). Glucose, insulin, C-peptide, glucagon, GLP-1, GIP, valine, leucine and isoleucine concentrations were measured. Results: Rise in serum BCAA was achieved in both BCAA tests, with incremental areas under the curve (iAUC) being 2.1 times greater for IV BCAA compared with those of the oral BCAA test (p &lt; 0.0001). Oral and IV BCAA induced comparable insulin response greater than placebo (240 min insulin iAUC: oral 3,411 +- 577 vs. IV 2,361 +- 384 vs. placebo 961.2 +- 175 pmol/L, p = 0.0006). Oral BCAA induced higher GLP-1 (p &lt; 0.0001) and GIP response (p &lt; 0.0001) compared with the IV or placebo. Glucose levels declined significantly (p &lt; 0.001) in the same pattern during both BCAA tests with no change in the placebo group. Conclusions: An equivalent dose of BCAA elicited a comparable insulin and greater incretin response when administered orally and not when administered through IV. We conclude that insulinotropic effects of BCAA are partially incretin dependent.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

<a href="/en/project/NT14416" target="_blank" >NT14416: Effect of branched-chain amino acids and saturated fatty acids on development of insulin resistance</a><br>

Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Annals of Nutrition &amp; Metabolism

ISSN

0250-6807

e-ISSN

—

Volume of the periodical

70

Issue of the periodical within the volume

4

Country of publishing house

CH - SWITZERLAND

Number of pages

10

Pages from-to

293-302

UT code for WoS article

000405094100005

EID of the result in the Scopus database

2-s2.0-85020450478