A vicious circle in chronic lymphoedema pathophysiology? An adipocentric view

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F17%3A43913401" target="_blank" >RIV/00216208:11120/17:43913401 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/obr.12565" target="_blank" >http://dx.doi.org/10.1111/obr.12565</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/obr.12565" target="_blank" >10.1111/obr.12565</a>

Result language
angličtina
Original language name
A vicious circle in chronic lymphoedema pathophysiology? An adipocentric view
Original language description
Chronic lymphoedema is a disease caused by a congenital or acquired damage to the lymphatic system and characterized by complex chains of pathophysiologic events such as lymphatic fluid stasis, chronic inflammation, lymphatic vessels impairment, adipose tissue deposition and fibrosis. These events seem to maintain and reinforce themselves through a positive feedback loop: regardless of the initial cause of lymphatic stasis, the dysfunctional adipose tissue and its secretion products can worsen lymphatic vessels' function, aggravating lymph leakage and stagnation, which can promote further adipose tissue deposition and fibrosis, similar to what may happen in obesity. In addition to the current knowledge about the tight and ancestral interrelation between immunity system and metabolism, there is evidence for similarities between obesity-related and lymphatic damage-induced lymphoedema. Together, these observations indicate strong reciprocal relationship between lymphatics and adipose tissue and suggest a possible key role of the adipocyte in the pathophysiology of chronic lymphoedema's vicious circle.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30202 - Endocrinology and metabolism (including diabetes, hormones)

Project
<a href="/en/project/GA16-00477S" target="_blank" >GA16-00477S: LYMPHAT- Lymphatic stasis as a modulator of adipose tissue expansion and inflammation</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)