A head-to-head comparison of 4-L polyethylene glycol and low-volume solutions before colonoscopy: which is the best? A multicentre, randomized trial

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F17%3A43915610" target="_blank" >RIV/00216208:11120/17:43915610 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/17:00098392 RIV/00216208:11130/17:10365571 RIV/65269705:_____/17:00067916 RIV/00064173:_____/17:N0000111 RIV/00064203:_____/17:10365571

Result on the web

<a href="http://dx.doi.org/10.1007/s00384-017-2901-x" target="_blank" >http://dx.doi.org/10.1007/s00384-017-2901-x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00384-017-2901-x" target="_blank" >10.1007/s00384-017-2901-x</a>

Result language

angličtina

Original language name

A head-to-head comparison of 4-L polyethylene glycol and low-volume solutions before colonoscopy: which is the best? A multicentre, randomized trial

Original language description

PURPOSE: The purpose of this study is to compare the efficacy and tolerability of polyethylene glycol (PEG) to sodium picosulfate/magnesium citrate (SPMC) and low-volume polyethylene glycol/ascorbic acid (PEGA) in a single- or split-dose regimen for colonoscopy bowel preparation. METHODS: This was a prospective, randomized, endoscopist-blinded, multicentre study. Outpatients received either PEG or SPMC or PEGA in a single or a split dose before the colonoscopy. Quality and tolerability of the preparation and complaints during preparation were recorded. RESULTS: Nine hundred seventy-three patients were analysed. Satisfactory bowel cleansing (Aronchick score 1 + 2) was more frequent when a split dose was used irrespective of the solution type (PEG 90.1 vs 68.8%, PEGA 86.0 vs 71.6%, SPMC 84.3 vs 60.2%, p &lt; 0.001). SPMC was the best tolerated followed by PEGA (p &lt; 0.006) and PEG as the worst (p &lt; 0.001). Tolerability did not correlate with the regimen and amount of the solution used. Female gender is associated with a higher incidence of nausea, vomiting and pain (p &lt; 0.029). CONCLUSIONS: Both PEG, PEGA and SPMC are fully comparable in terms of colonic cleansing when used in similar regimens. The split-dose preparation is more effective in all agents. SPMC and PEGA are better tolerated than PEG. The preparation regimen and/or the volume do not affect tolerability.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30219 - Gastroenterology and hepatology

Project

—

Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Colorectal Disease

ISSN

0179-1958

e-ISSN

—

Volume of the periodical

32

Issue of the periodical within the volume

12

Country of publishing house

DE - GERMANY

Number of pages

4

Pages from-to

1763-1766

UT code for WoS article

000415692100014

EID of the result in the Scopus database

2-s2.0-85029905735