Utilization and Reference Values of Bone Turnover Markers: Osteocalcin and Procollagen Type 1 N-Propeptide

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F17%3A43916323" target="_blank" >RIV/00216208:11120/17:43916323 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1007/978-94-007-7693-7_37" target="_blank" >https://doi.org/10.1007/978-94-007-7693-7_37</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-94-007-7693-7_37" target="_blank" >10.1007/978-94-007-7693-7_37</a>

Result language

angličtina

Original language name

Utilization and Reference Values of Bone Turnover Markers: Osteocalcin and Procollagen Type 1 N-Propeptide

Original language description

All body bones undergo continual remodeling. This process consists of bone resorption and bone formation which are closely coupled actions. Changes in bone tissue are accompanied by changes of biochemical markers. Plasma (and/or urine) concentration of these markers depends on bone resorption/formation activity, i.e., bone turnover rate. Osteocalcin is important noncollagenous protein in bone matrix, synthetized by osteoblasts and osteocytes. It is a good marker of bone turnover. Its undercarboxylated form has a role in regulation of energy metabolism. Osteocalcin is also involved in biosynthesis of testosterone or neurotransmitter production. Procollagen type 1 N-propeptide is a aminoterminal part of procollagen precursor cleaved by proteases during bone formation process. Its serum concentration is significantly related to newly formed collagen. Procollagen type 1 N-propeptide is supposed to be the most reliable biochemical marker of bone formation at present time. Reference values of both laboratory markers for central European population of children and adolescents are presented, and some data about reference intervals in adults from different ethnic groups are mentioned.

Czech name

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Czech description

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Type

C - Chapter in a specialist book

CEP classification

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OECD FORD branch

30211 - Orthopaedics

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Book/collection name

Biomarkers in Bone Disease

ISBN

978-94-007-7692-0

Number of pages of the result

14

Pages from-to

239-252

Number of pages of the book

1185

Publisher name

Springer

Place of publication

Dordrecht

UT code for WoS chapter

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