Endoscopically implantable devices into submucosa as the solution for low-gravity induced gastrointestinal problems

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F17%3A43916988" target="_blank" >RIV/00216208:11120/17:43916988 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Endoscopically implantable devices into submucosa as the solution for low-gravity induced gastrointestinal problems

Original language description

The future manned space missions will be challenging not only from technical point of view but medical as well. Although the process of selecting suitable candidates is rigorous, medical complications can still occur during longterm space flight. Gastrointestinal problems are a quite significant group of all medical events among astronauts. One of the main gastrointestinal problems is the gastroesophageal reflux disease (GERD). The gravity normally keeps the acid reflux from developing. However, in low gravity or microgravity, the acid can press against lower esophageal sphincter easier which may lead to GERD. We developed a method to address these challenges with a battery-less endoscopically implantable device. A miniature implantable capsule (14 mm x 14 mm x 6 mm) was designed to assess the technology. It is powered wirelessly using inductive coupling with the transmitter coil and features two-lead bipolar electrical stimulation. The experiments were performed in an animal model and living animals. The device was endoscopically implanted into submucosal space near lower esophageal sphincter. The device stimulates the muscularis propria inside esophagus to prevent GERD. Minimal invasiveness and virtually no bleeding during surgery when compared to today&apos;s solutions for neurostimulation make the presented solution a novel approach which could be carried out in space or before space flight without the need for full anaesthesia. Future work will be focused on implementing different types of sensors and actuators to treat different gastrointestinal diseases which could occur during long-term spaceflight.

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

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OECD FORD branch

30219 - Gastroenterology and hepatology

Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

Proceedings of the International Astronautical Congress; Vol. 3

ISBN

978-1-5108-5537-3

ISSN

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e-ISSN

neuvedeno

Number of pages

4

Pages from-to

1961-1964

Publisher name

International Astronautical Federation

Place of publication

Paris

Event location

Adelaide, Australia

Event date

Sep 25, 2017

Type of event by nationality

WRD - Celosvětová akce

UT code for WoS article

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